Search all Ray Truant’s publications here
Greatest Hits:
Poly ADP-Ribose Signaling is Dysregulated in Huntington’s Disease Patients
https://www.biorxiv.org/content/10.1101/2022.11.23.517669v1
Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.
High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry.
DNA Repair in Huntington’s Disease and Spinocerebellar Ataxias: Somatic Instability and Alternative Hypotheses.
Mod3D: A low-cost, flexible modular system of live-cell microscopy chambers and holders.
N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation
Bowie, L. E., Maiuri, T., Alpaugh, M., Gabriel, M., Arbez, N., Galleguillos, D., … Truant, R.
Proceedings of the National Academy of Sciences of the United States of America, 115(30), E7081–E7090.
PMID: 29987005
A Patient-Derived Cellular Model for Huntington’s Disease Reveals Phenotypes at Clinically Relevant CAG Lengths
Hung, C. L. K., Maiuri, T., Bowie, L. E., Gotesman, R., Son, S., Falcone, M., … Truant, R.
Mol Biol Cell. 2018; mbcE18090590.
PMID: 30256717
Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.
Maiuri T, Mocle AJ, Hung CL, Xia J, van Roon-Mom WM, Truant R.
Hum Mol Genet. 2017 Jan 15;26(2):395-406. doi: 10.1093/hmg/ddw395.
PMID: 28017939
DNA repair: A unifying mechanism in neurodegeneration.
Ross CA, Truant R.
Nature. 2017 Jan 5;541(7635):34-35. doi: 10.1038/nature21107. Epub 2016 Dec 21. No abstract available.
PMID: 28002410
Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization.
DiGiovanni LF, Mocle AJ, Xia J, Truant R.
Hum Mol Genet. 2016 Sep 15;25(18):3937-3945. doi: 10.1093/hmg/ddw234. Epub 2016 Jul 27.
PMID: 27466181
Paperpile
Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions.
Caron NS, Hung CL, Atwal RS, Truant R.
Hum Mol Genet. 2014 May 1;23(9):2324-38. doi: 10.1093/hmg/ddt625. Epub 2013 Dec 11.
PMID: 24335607
Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin.
Caron NS, Desmond CR, Xia J, Truant R.
Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14610-5. doi: 10.1073/pnas.1301342110. Epub 2013 Jul 29.
PMID: 23898200
Desmond CR, Maiuri T, Truant R.
Commun Integr Biol. 2013 Mar 1;6(2):e23318. doi: 10.4161/cib.23318.
PMID: 23750301
The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal.
Maiuri T, Woloshansky T, Xia J, Truant R.
Hum Mol Genet. 2013 Apr 1;22(7):1383-94. doi: 10.1093/hmg/dds554. Epub 2013 Jan 7.
PMID: 23297360 Similar articles
The role of the cofilin-actin rod stress response in neurodegenerative diseases uncovers potential new drug targets.
Munsie LN, Truant R.
Bioarchitecture. 2012 Nov-Dec;2(6):204-8. doi: 10.4161/bioa.22549.
PMID: 23267414 Similar articles
Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein.
Desmond CR, Atwal RS, Xia J, Truant R.
J Biol Chem. 2012 Nov 16;287(47):39626-33. doi: 10.1074/jbc.M112.412379. Epub 2012 Sep 25.
PMID: 23012356
Using FLIM-FRET to measure conformational changes of transglutaminase type 2 in live cells.
Caron NS, Munsie LN, Keillor JW, Truant R.
PLoS One. 2012;7(8):e44159. doi: 10.1371/journal.pone.0044159. Epub 2012 Aug 31.
PMID: 22952912
Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.
Di Pardo A, Maglione V, Alpaugh M, Horkey M, Atwal RS, Sassone J, Ciammola A, Steffan JS, Fouad K, Truant R, Sipione S.
Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3528-33. doi: 10.1073/pnas.1114502109. Epub 2012 Feb 13.
PMID: 22331905
Kinase inhibitors modulate huntingtin cell localization and toxicity.
Atwal RS, Desmond CR, Caron N, Maiuri T, Xia J, Sipione S, Truant R.
Nat Chem Biol. 2011 May 29;7(7):453-60. doi: 10.1038/nchembio.582.
PMID: 21623356
Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease.
Munsie L, Caron N, Atwal RS, Marsden I, Wild EJ, Bamburg JR, Tabrizi SJ, Truant R.
Hum Mol Genet. 2011 May 15;20(10):1937-51. doi: 10.1093/hmg/ddr075. Epub 2011 Feb 25.
PMID: 21355047
Lifeact cannot visualize some forms of stress-induced twisted F-actin.
Munsie LN, Caron N, Desmond CR, Truant R.
Nat Methods. 2009 May;6(5):317. doi: 10.1038/nmeth0509-317. No abstract available.
PMID: 19404250
Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases.
Truant R, Atwal RS, Desmond C, Munsie L, Tran T.
FEBS J. 2008 Sep;275(17):4252-62. doi: 10.1111/j.1742-4658.2008.06561.x. Epub 2008 Jul 15. Review.
PMID: 18637947
A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy.
Atwal RS, Truant R.
Autophagy. 2008 Jan;4(1):91-3. Epub 2007 Oct 22.
PMID: 17986868
Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.
Atwal RS, Xia J, Pinchev D, Taylor J, Epand RM, Truant R.
Hum Mol Genet. 2007 Nov 1;16(21):2600-15. Epub 2007 Aug 18.
PMID: 17704510