Blog post by Dr. Tamara Maiuri In a previous post, I described two new hypotheses generated by the findings of the HDSA-funded project looking for DNA repair-relevant huntingtin interacting proteins: that huntingtin binds poly ADP ribose (PAR), and that PAR signaling is dysregulated in HD. Last time, I reported our preliminary results supporting the first … Continue reading Hypothesis: Poly ADP ribose signaling is dysregulated in Huntington’s disease